IL-17AF Mouse anti-Human, PE, Clone: 20LJS09, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9179-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15557186

Quantity Price
1 £ 225.61 / 100 tests
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.5μg)/test
Applications Flow Cytometry (Intracellular Staining)
Monoclonal or Polyclonal Monoclonal
Clone 20LJS09
Host Species Mouse
Regulatory Status RUO
Format Conjugated
Conjugate PE
Primary or Secondary Primary
Isotype IgG1
Species Reactivity Human
Antigen IL-17AF
Gene Alias Interleukin-17AF
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 100 tests

The 20LJS09 monoclonal antibody reacts with human interleukin (IL)-17AF heterodimer. This antibody specifically reacts with this heterodimer and has no reactivity for IL-17A or IL-17F homodimers. IL-17A and IL-17F are well-characterized homodimeric cytokines secreted by T helper 17 (Th17) cells, gamma-delta T cells and several subsets of innate lymphoid cells. Somewhat less appreciated, IL-17A and IL-17F subunits can also form the heterodimer, IL-17AF. Together, these three dimers signal through the IL-17RA/IL-17RC receptor complex to mediate immune responses at mucosal interfaces and are found at lesion sites in inflammatory bowel disease, asthma, atopic dermatitis and rheumatoid arthritis.