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IL-17A Monoclonal Antibody (eBio17B7), eFluor™ 506, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

£214.00

Specifications

Antigen IL-17A
Clone eBio17B7
Applications Flow Cytometry
Classification Monoclonal
Conjugate eFluor 506
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Products 1
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15580697
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Affymetrix eBioscience
69-7177-82
100 μg
£214.00
100µg
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Estimated Shipment: 08-05-2024
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Description

Description

Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. The cDNA encoding human IL-17A was isolated from a library of CD4+ T cells; the encoded protein exhibits 72 percent amino acid identity with HVS13 , an open reading frame from a T lymphotropic Herpesvirus saimiri, and 63 percent with mouse CTLA-8 (cytotoxic T-lymphocyte associated antigen-8). Human IL-17A exists as glycosylated 20-30 kD homodimers. High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells. IL-17A enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. Human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A binds to a receptor that binds also to HVS13 (viral IL-17A) and to CTLA-8.

IL-17A Monoclonal antibody specifically detects IL-17A in Mouse, Rat samples. It is validated for Flow Cytometry.
Specifications

Specifications

IL-17A
Flow Cytometry
eFluor 506
Rat
Mouse, Rat
IgG2a κ
Affinity chromatography
eBio17B7
Monoclonal
Liquid
RUO
16171, 301289
Primary
Antibody
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