IL-15 Mouse anti-Human, Clone: ct2nu, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-0157-85

500UG:ANTI-HUMAN IL-15 FUNCTIONAL GRADE PURIFIED

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15268387

Quantity Price
1 £ 201.0 / 500µg
Estimated Shipment date
from Supplier 23-01-2017
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Description and Specification

Specification

Antigen IL-15
Applications Cytokine Neutralization
Clone ct2nu
Concentration 1mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, no sodium azide
Host Species Mouse
Isotype IgG1
Quantity 500μg
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C. Avoid repeated freeze/thaw cycles. KEEP CONTENTS STERILE.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The ct2nu monoclonal antibody reacts with human IL-15 and neutralizes its bioactivity. IL-15, or IL-T, is a 14kDa proinflammatory cytokine and member of the IL-2 family. It plays a role in the development and maturation of macrophages and dendritic cells, and is essential to the proliferation and survival of NK cells and CD8+ T cells.

IL-15 is expressed by antigen-presenting cells, epithelial cells, and stromal cells. IL-15 activates the Jak/STAT pathway through its heterotrimeric receptor. Two subunits of this receptor, the β and γ chains, are shared with the rest of the family, while the α subunit is unique to IL-15. In mice, the α chain is required to chaperone IL-15 from the ER to secretion. This chaperoning is not necessary in humans, and free IL-15 is detectable in human biological samples. However, the receptor-cytokine complex has been indentified in humans and demonstrates agonistic activity several-fold higher than IL-15 alone.