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IL-15 Mouse anti-Human, Clone: ct2nu, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-0157-85

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15268387

  • £170.59 / 500µg


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For Research Use Only.


Description

Description

The ct2nu monoclonal antibody reacts with human IL-15 and neutralizes its bioactivity. IL-15, or IL-T, is a 14kDa proinflammatory cytokine and member of the IL-2 family. It plays a role in the development and maturation of macrophages and dendritic cells, and is essential to the proliferation and survival of NK cells and CD8+ T cells.

IL-15 is expressed by antigen-presenting cells, epithelial cells, and stromal cells. IL-15 activates the Jak/STAT pathway through its heterotrimeric receptor. Two subunits of this receptor, the β and γ chains, are shared with the rest of the family, while the α subunit is unique to IL-15. In mice, the α chain is required to chaperone IL-15 from the ER to secretion. This chaperoning is not necessary in humans, and free IL-15 is detectable in human biological samples. However, the receptor-cytokine complex has been indentified in humans and demonstrates agonistic activity several-fold higher than IL-15 alone.
Specifications

Specifications

IL-15
ct2nu
Unconjugated
Purified
IgG1
RUO
Primary
Human
Cytokine Neutralization
1mg/mL
aqueous buffer, no sodium azide
Murine
500μg
Store at 2-8°C. Avoid repeated freeze/thaw cycles. KEEP CONTENTS STERILE.
Monoclonal
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