IL-13 Rat anti-Mouse, Clone: eBio1316H, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-7135-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288767

Quantity Price
1 £ 176.7 / 500µg
EU Stock 7
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Description and Specification

Specification

Concentration 1mg/mL
Storage Requirements Store at 2-8°C.
Regulatory Status RUO
Quantity 500μg
Format Purified
Monoclonal or Polyclonal Monoclonal
Antigen IL-13
Clone eBio1316H
Conjugate Unlabeled
Formulation aqueous buffer, no sodium azide
Species Reactivity Mouse
Primary or Secondary Primary
Isotype IgG1
Applications Cytokine Neutralization
Gene Alias Interleukin-13
Host Species Rat

The eBio1316H antibody reacts with mouse IL-13. The eBio1316H antibody is a neutralizing antibody. Mouse interleukin-13 (IL-13), originally designated p600, is a 11.6kDa protein secreted by activated T helper cells, CD8+ T cells, and NK cells. IL-13 was originally identified in 1989 through differential hybridization of cDNA libraries prepared from T helper 1 and T helper 2 cells. IL-13 contains four cysteine residues, which form two intramolecular disulfide bonds. IL-13 shares many activities with IL-4; this relates to a requirement for IL-4Ralpha chain for signal transduction. The biological activities of IL-13 include suppression of macrophage cytotoxic activity, upregulation of IL-1RA expression, and suppression of inflammatory cytokine expression. IL-13 induces CD23 expression on B cells and enhances CD72, and expression of class II MHC gene products. Mouse IL-13 does not display the activities on T cells and B cell stimulatory effects which IL-4 exhibits. Mouse IL-13 is active on human and mouse cells.