IL-12 Rat anti-Mouse, Clone: C18.2, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-7122-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15268017

Quantity Price
1 £ 54.42 / 50µg
Estimated Shipment date
from Supplier 02-05-2017
Add to basket


Description and Specification

Specification

Applications Cytokine Neutralization
Applications ELISA Capture
Monoclonal or Polyclonal Monoclonal
Clone C18.2
Gene Alias Interleukin-12
Quantity 50μg
Antigen IL-12
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Mouse
Primary or Secondary Primary
Isotype IgG2a
Storage Requirements Store at 2-8°C.
Format Purified
Concentration 0.5mg/mL
Conjugate Unlabeled
Host Species Rat
Regulatory Status RUO

The C18.2 antibody reacts with the p35 subunit of mouse interleukin-12 (IL-12). Interleukin-12 (IL-12) is a heterodimeric 70 kD (p70) cytokine composed of two covalently linked, glycosylated chains, 40kD (p40) and 35-kD (p35). IL-12 is mainly produced by monocytes, macrophages, and dendritic cells in response to bacterial products such as lipopolysaccharides (LPS), to intracellular pathogens or upon interaction with activated T cells. IL-12 was originally discovered because of its ability to induce interferon-gamma (IFN-g) production, cell proliferation, and cytotoxicity mediated by natural killer cells and T cells. It is now established that IL-12 also plays a key role in the development of Th1 responses, leading to IFN-g and IL-2 production. These cytokines can in turn promote T-cell responses and macrophage activation.