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IL-12 Rat anti-Mouse, Clone: C18.2, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-7122-81

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15268017

  • £54.42 / 50µg


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For Research Use Only.


Description

Description

The C18.2 antibody reacts with the p35 subunit of mouse interleukin-12 (IL-12). Interleukin-12 (IL-12) is a heterodimeric 70 kD (p70) cytokine composed of two covalently linked, glycosylated chains, 40kD (p40) and 35-kD (p35). IL-12 is mainly produced by monocytes, macrophages, and dendritic cells in response to bacterial products such as lipopolysaccharides (LPS), to intracellular pathogens or upon interaction with activated T cells. IL-12 was originally discovered because of its ability to induce interferon-gamma (IFN-g) production, cell proliferation, and cytotoxicity mediated by natural killer cells and T cells. It is now established that IL-12 also plays a key role in the development of Th1 responses, leading to IFN-g and IL-2 production. These cytokines can in turn promote T-cell responses and macrophage activation.
Specifications

Specifications

IL-12
C18.2
Unconjugated
Purified
Rat
50μg
Store at 2-8°C.
Monoclonal
ELISA Capture
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-12
IgG2a
RUO
Primary
Murine
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