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IL-12 Mouse anti-Mouse, Clone: MMp35A1.6 (A1.6), Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-7360-85

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15587816

  • £207.27 / 500µg


Estimated Shipment date
from Supplier 01-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The MMp35A1.6 (A1.6) antibody reacts with the p35 subunit of mouse interleukin-12 (IL-12) and inhibits IL-12 bioactivity (in vitro and in vivo) but not the bioactivity of IL-35. p35 is a component of two of the four members of the interleukin (IL)-12 family of cytokines. The IL-12 family members are heterodimeric cytokines composed of an alpha-chain, such as p35, and a beta-chain, such as p40. The alpha-chain proteins are thought to be the limiting factors for secretion of IL-12 family member cytokines, as expression of the alpha-chain is more restricted than that of the beta-chain proteins, and the two subunits may need to be co-expressed in order for cytokine secretion to occur. IL-12 family members are secreted primarily by antigen-presenting cells in response to various TLR agonists and other inflammatory stimuli. The exact types of stimuli present and kinetics of stimulation determine the balance of IL-12 family member production.

The p35 protein was first identified as part of the IL-12 cytokine, which is also known as IL-12p70. Secretion is induced by IFN gamma and agonists of TLR3, 4, or 7 and is inhibited by Th2 cytokines. IL-12 is essential for the differentiation and maintenance of Th1 cells. The other subunit, p40, is expressed in much higher quantities than p35, and may be secreted independently as a monomer or homodimer. Free p40 may act as an antagonist of IL-12 function.

More recently, p35 was also found to dimerize with EBI3 (Epstein-Barr Virus-Induced Gene 3) to form IL-35. The biology of IL-35 is incompletely understood, and it is believed to be unique among the IL-12 family members in its expression and function. It is produced by regulatory T cells, and appears to have immunoregulatory functions. IL-35 has been found to suppress the proliferation and function of effector T cells, and has also been observed to induce a regulatory phenotype on naïve CD4+ cells cultured in its presence.
Description & Specifications

Specifications

IL-12
MMp35A1.6 (A1.6)
Unlabeled
aqueous buffer, no sodium azide
Murine
500μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
Purified
Interleukin-12 p35
IgG2a
RUO
Primary
Murine