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IL-12 p35 Monoclonal Antibody (4D10p35), eFluor™ 660, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

£108.00 - £263.00

Specifications

Antigen IL-12 p35
Clone 4D10p35
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
15520037
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Affymetrix eBioscience
50-7352-80
25 μg
£108.00
25µg
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Estimated Shipment: 07-05-2024
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15530037
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Affymetrix eBioscience
50-7352-82
100 μg
£263.00
100µg
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Estimated Shipment: 07-05-2024
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Description

Description

Description: This 4D10p35 monoclonal antibody reacts with mouse p35, a component of two of the four members of the interleukin (IL)-12 family of cytokines. The IL-12 family members are heterodimeric cytokines composed of an alpha-chain, such as p35, and a beta-chain, such as p40. The alpha-chain proteins are thought to be the limiting factors for secretion of IL-12 family member cytokines, as expression of the alpha-chain is more restricted than that of the beta-chain proteins, and the two subunits may need to be co-expressed in order for cytokine secretion to occur. IL-12 family members are secreted primarily by antigen-presenting cells in response to various TLR agonists and other inflammatory stimuli. The exact types of stimuli present and kinetics of stimulation determine the balance of IL-12 family member production. The p35 protein was first identified as part of the IL-12 cytokine, which is also known as IL-12p70. Secretion is induced by IFN gamma and agonists of TLR3, 4, or 7 and is inhibited by Th2 cytokines. IL-12 is essential for the differentiation and maintece of Th1 cells. The other subunit, p40, is expressed in much higher quantities than p35, and may be secreted independently as a monomer or homodimer. Free p40 may act as an antagonist of IL-12 function. More recently, p35 was also found to dimerize with EBI3 (Epstein-Barr Virus-Induced Gene 3) to form IL-35.

IL-12 p35 Monoclonal antibody specifically detects IL-12 p35 in Mouse samples. It is validated for Flow Cytometry.
Specifications

Specifications

IL-12 p35
0.2 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
CLMF; CLMF p35; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; il 12; IL-12 subunit p35; IL-12, subunit p35; Il12a; IL-12A; IL12p35; IL-12p35; IL35 subunit; ILN; Interleukin; Interleukin 12; interleukin 12 p35 subunit; interleukin 12, p35; interleukin 12a; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); Interleukin12; interleukin-12 alpha chain; interleukin-12 beta p35 subunit; interleukin-12 p35 subunit; interleukin-12 subunit alpha; Ll12a; NF cell stimulatory factor chain 1; NFSK; NK cell stimulatory factor chain 1; NKSF1; P35
IL12A
IgG2a κ
Affinity chromatography
Antibody
4D10p35
Flow Cytometry
eFluor 660
Rat
Mouse
P43431
16159
Mouse IL-35-Fc recombinant protein
Primary
4° C, store in dark, DO NOT FREEZE!
IL12A
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