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IL-12/IL-23 p40, Functional Grade, clone: C17.8, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-7123-38

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15597806

  • £1201.25 / 5mg


Estimated Shipment date
from Supplier 01-06-2018
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Description

Description

Description: The C17.8 antibody reacts with the p40 subunit of IL-12 and IL-23. The C17.8 antibody has been found to neutralize IL-12 and IL-23 bioactivity. For specific neutralization of IL-23 only, please see clone G23-8 (anti-mouse IL-23 p19). IL-12 is a 70kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and is secreted by activated monocytes, macrophages, and dendritic cells. IL-23 is a heterodimer composed of the disulfide-linked p19 protein and p40 protein, expressed by activated dendritic cells.Applications Reported: The C17.8 antibody has been reported for use in IP, Western, ELISA, neutralization, and intracellular staining for flow cytometric analysis.Applications Tested: The Functional Grade Purified C17.8 antibody has been tested by LAL assay to verify low endotoxin levels and has been tested for ELISA detection and in bioassay for neutralization of IL-12 p70 and IL-23 bioactivity. The C17.8 antibody at 62.0 ng/mL has been found to inhibit by 50% the biological effects of 1 ng/mL mouse IL-12 p70 (14-8121) or mouse IL-23 (14-8231), in corresponding bioassay. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in the BestProtocols® section.Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.Storage and handling: Use in a sterile environment.Filtration: 0.2μm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.
Specifications

Specifications

IL-12/IL-23
Monoclonal
1mg/mL
PBS with no preservative; pH 7.2
P43432
IL12B, Il12p40, interleukin 12B, RP23-388G23.1, Il-12b, Il-12p40, p40, IL-12 p40, IL-23 subunit p40, IL12P40
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Western Blot
C17.8
Functional Grade
Il12b
Purified
Il12b
IgG2a, kappa
5mg
Store at 2-8°C.
Primary
16160
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