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IL-12/IL-23 p40, clone: C8.6, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-7129-81

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15228027

  • £56.38 / 50µg


Estimated Shipment
31-07-2018
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Description

Description

Description: The C8.6 antibody reacts with the p40 subunit of human IL-12 p70 and human IL-23. IL-12 is a 70kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and secreted primarily by activated monocytes, macrophages, and dendritic cells. IL-23 is a biologically-related, heterodimeric cytokine composed of disulfide-linked p40 and p19 subunits.Applications Reported: Unlabeled C8.6 has been reported for use as a cold mAb control to block fluorochrome conjugated C8.6 in staining of intracellular IL-12 and in immunblotting under nonreducing conditions. C8.6 has also been reported for use in cytokine neutralization. (Please use Functional Grade purified C8.6, cat. 16-7129, in functional assays.).Applications Tested: The unconjugated C8.6 antibody has been tested as a cold mAb control to block fluorochrome conjugated C8.6 in staining of intracellular IL-12 and nonreducing immunoblots at 2 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

IL-12/IL-23
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P29460
IL12B, Il12p40, interleukin 12B, RP23-388G23.1, Il-12b, Il-12p40, p40, IL-12 p40, IL-23 subunit p40, IL12P40
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Cytokine NeutralizationþFlow CytometryþWestern Blot
C8.6
Unconjugated
IL12B
Purified
IL12B
IgG1, kappa
50μg
Store at 2-8°C.
Primary
3593
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