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IL-10 Rat anti-Mouse, Functional Grade, Clone: JES5-16E3, eBioscience™

Rat Monoclonal Antibody

£58.50 - £1128.00

Specifications

Antigen IL-10
Clone JES5-16E3
Target Species Mouse
Conjugate Functional Grade
Isotype IgG2b, kappa
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15268757
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Affymetrix eBioscience
16-7101-81
50 μg
£58.50
50µg
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Estimated Shipment
07-12-2020
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15278757
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Affymetrix eBioscience
16-7101-85
500 μg
£186.00
500µg
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Estimated Shipment
07-12-2020
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15577806
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Affymetrix eBioscience
16-7101-38
5mg
£1128.00
5mg
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Estimated Shipment
07-12-2020
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Description

Description

Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. Interleukin 10 (IL-10, CSIF) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 is an 18.6 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein (BCRFI). The reported biological activities of IL-10, which maybe interrelated, include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells, enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). IL-10 inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Knockout studies in mice suggest the function of this cytokine as an essential immunoregulator in the intestinal tract.
Specifications

Specifications

IL-10
Mouse
IgG2b, kappa
Monoclonal
Liquid
Antibody
4° C
JES5-16E3
Functional Grade
ELISA, Functional Assay, Neutralization
Primary
Monoclonal
PBS with no preservative; pH 7.2
RUO
SDS

For Research Use Only.