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IL-1 beta Polyclonal Antibody, Biotin, eBioscience™, Invitrogen™

Rabbit Polyclonal Antibody

£91.75 - £274.00

Specifications

Antigen IL-1 beta
Concentration 0.5 mg/mL
Applications ELISA
Classification Polyclonal
Conjugate Biotin
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15310040
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Affymetrix eBioscience
13-7112-81
50 μg
£91.75
50µg
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Estimated Shipment: 08-05-2024
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15320040
View Documents Promotion Details
Affymetrix eBioscience
13-7112-85
500 μg
£274.00
500µg
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»
Estimated Shipment: 08-05-2024
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Description

Description

Description: The biotinylated polyclonal rabbit antibody reacts with mouse interleukin-1beta (IL-1beta), a 17 kDa factor secreted primarily by monocytes. IL-1 has effects on T-helper cells, inducing IL-2 secretion and expression of IL-2 receptors. IL-1 has effects on B cells, promoting cell proliferation and immunoglobulin synthesis. Applications Reported: Biotin anti-mouse interleukin-1 beta (IL-1 beta) has been reported for use as the detection antibody for a mouse IL-1 beta ELISA. Applications Tested: The biotinylated polyclonal rabbit anti-mouse IL-1 beta antibody has been tested as the detection antibody in a sandwich ELISA for analysis of mouse IL-1 beta in combination with the unlabelled B122 (14-7012) antibody for capture and recombinant mouse IL-1 beta (14-8012) as the standard. A suitable range of concentrations of this antibody for ELISA detection is 1.0 - 6.0 μg/mL. A standard curve consisting of doubling dilutions of the recombinant standard over the range of 2000 pg/mL - 15 pg/mL should be included in each ELISA plate. Filtration: 0.2 μm post-manufacturing filtered.

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
Specifications

Specifications

IL-1 beta
ELISA
Biotin
Rabbit
Mouse
P10749
16176
IgG
Affinity chromatography
Antibody
0.5 mg/mL
Polyclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1β; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1B; IL1B1; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1β; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1b; interleukin-1beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta
IL1B
Primary
4° C, store in dark, DO NOT FREEZE!
IL1B
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