Ikaros Mouse anti-Mouse, Clone: 2A9-mIkaros, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5780-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15277457

Quantity Price
1 £ 78.88 / 25µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Applications Western Blot
Host Species Murine
Format Purified
Concentration 0.5mg/mL
Antigen Ikaros
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Gene Alias IZKF1
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Clone 2A9-mIkaros
Quantity 25μg
Conjugate Unlabeled
Isotype IgG1
Regulatory Status RUO

This 2A9-mIkaros monoclonal antibody reacts with mouse Ikaros, the 70kDa founding member of the Ikaros family of C2H2-type zinc finger transcription factors. Ikaros is expressed in hematopoietic progenitor cells, thymocytes, mature T and B cells, monocytes, macrophages, and natural killer cells. This protein has also been shown to be expressed in non-immune cells such as neurons. Studies indicate that Ikaros can interact with other family members, namely Aiolos and Eos. Ikaros is involved in thymocyte development, B cell differentiation, cell cycle control, chromatin remodeling, and tumor suppression. Moreover, Ikaros has been implicated in leukemia and lymphoma. Ikaros has been demonstrated to regulate expression of Tdt, CD8a, and Notch target genes.

At least eight Ikaros isoforms exist due to alternative splicing. The 2A9-mIkaros antibody has been reported to recognize Ikaros isoform VI (Ik-6), which is the longest and most predominant.