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Invitrogen™ IgE Human Uncoated ELISA Kit

For quantitative detection of human IgE.

£367.00 - £556.00

Specifications

Sample Type Plasma, Serum
Target Species Human
For Use With (Application) ELISA
Synonym Immunoglobulin E
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
15530957
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Invitrogen™
88-50610-77
20 x 96 Tests
£556.00
Pack of 20
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Estimated Shipment: 09-04-2024
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15550957
View Documents Promotion Details
Invitrogen™
88-50610-88
10 x 96 Tests
£367.00
Pack of 10
View alternative products
Save Up to 
»
Estimated Shipment: 22-04-2024
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Add to basket
 
Description

Description

The Human Immunoglobulin E (Hu IgE) Uncoated ELISA Kit contains pre-matched antibody pairs, plates and reagents for performing quantitative enzyme linked immunosorbent assays (ELISA) to detect and quantify protein levels of human IgE. Wash Buffer and Stop Solution are needed to complete the ELISA reaction and are sold separately. Principle of the method ELISAs are designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody is coated to the bottom of the wells of a microplate, which is an overnight process. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. A sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.

IgE is one of the five classes of immunoglobulins found in mammals. Monomers consist of two heavy (epsilon) chains with 4 Ig-like constant domains, and two light chains. IgE plays an essential role in type I hypersensitivity (allergic responses such as hay fever, asthma, hives, anaphylatic shock) by binding to Fc receptors on basophils and mast cells. Crosslinking of IgE bound to Fc receptors induces degranulation of mast cells and basophils that promote allergic manifestations. IgE is also functionally important for immunity against parasites.
Specifications

Specifications

Plasma, Serum
Human
ELISA
Immunoglobulin E
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