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IFNAR1, Functional Grade, clone: MAR1-5A3, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-5945-38

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15557796

  • £1222.21 / 5mg


Estimated Shipment date
from Supplier 26-02-2018
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Disclaimers:

For Research Use Only.


Description

Description

Description: The MAR1-5A3 monoclonal antibody reacts with mouse IFN alpha/beta receptor subunit 1 (IFNAR-1). The type I IFN receptor subunit 1 is co-expressed with IFNAR-2 on nearly all cells and make up the heterodimeric receptor complex that binds to all type I IFNs, IFN alpha and IFN beta. Type I IFNs are a group of structurally and functionally related proteins that demonstrate antiviral, antiparasitic, and antiproliferative activities.Applications Reported: The MAR1-5A3 antibody has been reported for use in neutralization of IFNAR1 bioactivity.Applications Tested: The Functional Grade Purified MAR1-5A3 antibody has been tested by LAL assay to verify low endotoxin levels, by bioassay for neutralization of mouse IFNAR-1bioactivity. The MAR1-5A3 antibody at 0.04 μg/mL has been found to inhibit by 50% the biological effects of 0.5 ng/mL mouse IFN-a2 (ND50), in an EMCV assay of L929 cell protection. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in Best Protocols® section.Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.Storage and handling: Use in a sterile environment.Filtration: 0.2μm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.
Specifications

Specifications

IFN alpha receptor 1 (IFNAR1)
MAR1-5A3
Unconjugated
Purified
IgG1
RUO
Primary
Murine
Cytokine Neutralization
1mg/mL
aqueous buffer, no sodium azide
Murine
5mg
Store at 2-8°C.
Monoclonal
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