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Hydroxyurea, 98%, Thermo Scientific Chemicals

Catalog Number 10795991
37.65 GBP valid until 2024-12-31
Use promo code "22914" to get your promotional price.


31.93 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.


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Quantity:
5 g
25 g
100 g
Packaging:
Glass bottle
This item is not returnable. View return policy
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
127-07-1
CH4N2O2
76.04
MFCD00007943
VSNHCAURESNICA-UHFFFAOYSA-N
hydroxycarbamide, n-hydroxyurea, hydrea, 1-hydroxyurea, oxyurea, carbamoyl oxime, biosupressin, hydroxycarbamine, onco-carbide, carbamohydroxamic acid
3657
CHEBI:44423
hydroxyurea
C(=O)(N)NO
This item is not returnable. View return policy
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
127-07-1
CH4N2O2
76.04
MFCD00007943
VSNHCAURESNICA-UHFFFAOYSA-N
hydroxycarbamide, n-hydroxyurea, hydrea, 1-hydroxyurea, oxyurea, carbamoyl oxime, biosupressin, hydroxycarbamine, onco-carbide, carbamohydroxamic acid
3657
CHEBI:44423
hydroxyurea
C(=O)(N)NO

Hydroxyurea, 98%, CAS # 127-07-1, is a compound with antineoplastic, immunomodulatory, radical scavenger, and antimitotic activities. It shows inhibitory activity against nucleic acid synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Hydroxyurea is a member of the class of urea that shows antineoplastic, immunomodulatory, radical scavenger, and antimitotic activities.

• It has inhibitory activity against nucleic acid synthesis.

• It also inhibits ribonucleoside diphosphate reductase, an enzyme necessary to convert ribonucleoside diphosphate into deoxyribonucleoside diphosphate, preventing cells from leaving the G1/S phase of the cell cycle

Applications

• Hydroxyurea has an anti-retroviral activity, inhibiting human immunodeficiency virus type 1 (HIV-1) DNA synthesis in peripheral blood lymphocytes, decreasing the amount of intracellular deoxynucleotides

• This compound also has a radio sensitizing activity, maintaining cells in the radiation-sensitive G1 cell cycle phase and, consequently, interfering with DNA repair

• It has been used for cell cycle synchronization in human breast carcinoma cells

• This compound presents inhibitory activity in cell adhesion and motility assay in ccRCC Caki (HTB-47) and CD9 knockdown cells

TRUSTED_SUSTAINABILITY
Melting Point 142°C to 146°C
Color White
Loss on Drying 1% max. (1 g, 60°C) (< 0.7 kPa)
Infrared Spectrum Authentic
Assay Percent Range 97.5% min. (on dried substance) (Iodometry)
Packaging Glass bottle
Linear Formula HONHCONH2
Quantity 5 g
Beilstein 03, 95
Merck Index 15, 4888
Solubility Information Solubility in water: freely soluble. Other solubilities: freely soluble in hot alcohol
Formula Weight 76.04
Percent Purity 98%
Physical Form Crystalline Powder
Chemical Name or Material Hydroxyurea
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Product Identifier
  • Hydroxyurea
Signal Word
  • Danger
Hazard Category
  • Germ cell mutagenicity Category 1B
  • Reproductive toxicity Category 1A
Hazard Statement
  • H360D-May damage the unborn child.
  • H340-May cause genetic defects.
Precautionary Statement
  • P201-Obtain special instructions before use.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only

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