Proteintech HumanKine™ recombinant human IL-12 beta protein

Product Code. 17650087

Brand: Proteintech HZ13211000UG

Description

HumanKine™ recombinant protein

IL-12p40, also known as IL-12B, is a subunit of both the IL-12 and IL-23 cytokines. It is not thought to be bioactive on its own, but it has been shown to regulate IL-12 activity in antagonistic manner by competitively binding with the IL-12 receptor. IL-12p40 also functions as a chemoattractant molecule for macrophage infiltration into tumor sites. There has additionally been evidence to suggest that IL-12p40 mediates a protective immune response against mycobacterial infection by serving as a necessary component for granuloma formation and promoting Th1 effector cell functions (PMID: 17126601, 10453037, 11739515).

Specifications

• Accession Number: P29460
• Formulation: 1 x PBS pH 7.4
• Gene ID (Entrez): 3593
• Molecular Weight (g/mol): 37-50 kDa
• Quantity: 1000 μg
• Source: HEK293
• Storage Requirements: Lyophilized product should be stored at -20°C to -80°C until expiry date and (at Room Temperature for 2 weeks.)
• Endotoxin Concentration: <0.1 EU/μg
• Specific Reactivity: Human
• Recombinant: Recombinant
• Reconstitution: Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1 xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
• Form: Lyophilized
• Purity or Quality Grade: >95%