ACROBiosystems Human Siglec-10 Protein, Mouse IgG2a Fc Tag, low endotoxin

low endotoxin

Brand:  ACROBiosystems SI0-H525b-100ug

Product Code. 16478039

Description

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 85.6 kDa. The protein migrates as 90-120 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

• Accession Number: NP_149121.2
• Quantity: 100 μg
• Immunogen: Met 17 - Thr 546
• Gene Alias: SIGLEC10,MGC126774,PRO940,Siglec10,SLG2
• Conjugate: Unconjugated
• Protein Tag: Mouse IgG Fc Tag
• Endotoxin Level: Less than 0.1 EU / μg by the LAL method.
• Form: Powder
• Purity or Quality Grade: >95% as determined by SDS-PAGE

• Molecular Weight (g/mol): 85.6 kDa
• Source: Human Siglec-10, Mouse IgG2a Fc Tag, low endotoxin (SI0-H525b) is expressed from human 293 cells (HEK293). It contains AA Met 17 - Thr 546 (Accession # Q96LC7-1).
• Storage Requirements: -20°C
• Common Name: Siglec-10
• Species: Human
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Expression System: HEK293
• Protein Subtype: Bio-Markers and CD Antigens