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Invitrogen™ MMP9 Human ELISA Kit

For the quantitative detection of human MMP-9.

Brand:  Invitrogen™ BMS2016-2TEN

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15591487

  • £2250.00 / Pack of 10


Estimated Shipment
03-11-2020
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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human MMP-9
Biotin-Conjugate anti-human MMP-9 polyclonal antibody
Streptavidin-HRP
Human MMP-9 Standard lyophilized, 30ng/mL upon reconstitution
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins. MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa. MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis. Further, MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm.
Specifications

Specifications

P14780
Biotin
4318
ELISA Kit
0.05 ng/mL
Plasma, 10 μL|Serum, 10 μL|Supernatant, 10 μL
1 hr. 20 min.
Human
92 kDa gelatinase, Gelatinase B, GELB
7.3%
Human
HRP
0.23-15.0 ng/mL
ELISA
Pre-coated 96 well plate, Adhesive Plate Covers, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Controls
RUO
10 μL (1:25 prediluted)
2°C to 8°C
3 hr. 10 min.
CLG4B,GELB,MANDP2,MMP-9
10.2%
10 x 96 Tests
Supernatant
Colorimetric Microplate Reader
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For Research Use Only