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Invitrogen™ TGF beta-1 (LAP) Human ELISA Kit

Sandwich ELISA Kit

Brand:  Invitrogen™ BMS2065

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15571577

  • £377.00 / 96 tests


EU Stock 3
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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human LAP

Description

Description

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
Specifications

Specifications

P01137
Biotin
7040
Pre-coated 96 well plate, Adhesive Plate Covers, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Controls
RUO
10 μL
2°C to 8°C
3 hr. 30 min.
CED,DPD1,LAP,TGFB,TGFbeta
6%
HRP
Human
0.16-10 ng/mL
ELISA
Colorimetric Microplate Reader
ELISA Kit
0.098 ng/mL
Plasma, 10 μL|Serum, 10 μL|Supernatant, 10 μL
1 hr. 20 min.
Human
Latency Associated Peptide
7.6%
96 Tests
Supernatant
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For Research Use Only