eBioscience™ Human Activin A, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Overview
Brand: eBioscience™

Manufacturer Part Number: 34-8993-85

500UG Human Activin A Protein Carrier-Free

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15528846

Quantity Price
1 £ 1322.0 / 500µg
Estimated Shipment date
from Supplier 13-12-2016
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Description and Specification

Specification

Accession Number NM_002192
Concentration 0.5mg/mL
Conjugate Unlabeled
Cross Reactivity Human
For Use With (Application) Cytokine Bioassays
Formulation Sterile liquid: 20mM glycine, 150mM NaCl pH 3.0. 0.22μm filtered.
Molecular Weight 26kDa
Name Activin A
Purification Method SDS-PAGE
Purity ≥95%
Quantity 500μg
Recombinant Yes
Source Insect Cells
Storage Requirements Store at less than or equal to -70°C.
Regulatory Status RUO
Structural Form Insect expressed amino acids Gly311-Ser426, accession number NM_002192
Endotoxin Concentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Biological Activity The ED50 of this protein, as measured by inhibition of MPC-11 mouse plasmacytoma cell proliferation, is 0.75-3ng/mL. This corresponds to a specific activity of 1.3 x 106 - 3.3 x 105 Units/mg.
Product Type Recombinant Protein, Carrier-Free

Activin A is a member of the TGF-β superfamily, along with the other activin proteins and the structurally related inhibins. The activins are dimeric proteins formed by the association of two of the four existing β subunits, βA, βB, βC, and βE. These subunits are shared with the inhibin proteins, which are heterodimers of one β and one α chain. Activin A is a homodimer of two 13 kDa βA subunits, which can also associate with βB or βC to form Activin AB or AC, respectively. Activin A is expressed by various cell types and exhibits pleiotropic effects including the regulation of metabolism, homeostasis, cell proliferation and differentiation, apoptosis, and tissue healing. Activin A has been recently reported to work in synergy with TGF-β to promote the induction of antigen specific iTreg cells leading to inhibition of Th1 and Th2-mediated responses.