eBioscience™ Human IL-6, Recombinant Protein

Human Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8069-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15587486

Quantity Price
1 £ 158.36 / 25µg
EU Stock 50
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Description and Specification

Specification

For Use With (Application) Cytokine Bioassays
Molecular Weight The methionylated N-terminal protein has a predicted molecular mass of 21,041. The DTT-reduced and non-reduced protein migrate as 16kDa polypeptides on SDS-PAGE.
Regulatory Status RUO
Recombinant Yes
Cross Reactivity Human
Accession Number AF372214
Gene Symbol Interleukin-6, IL6
Quantity 25μg
Purification Method SDS-PAGE
Source E. coli
Structural Form E. coli expressed amino acids Pro 29-Met 212 of mature human IL-6 accession # AF372214
Endotoxin Concentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Conjugate Unlabeled
Name IL-6
Purity >98%
Biological Activity Measured by human TF-1 cell proliferation assay. The ED50 is 0.1ng/mL, corresponding to a specific activity of 1.0 x 107 Units/mg.
Validated Application FA
Formulation Sterile liquid; 10mM sodium phosphate, pH 7.2, 150mM NaCl, 0.5% BSA. 0.22μm filtered.

Human IL-6 (also known as B Cell Stimulating Factor BCSF, BSF-2) is a ∽21-28 kDa factor produced by a variety of cell types including monocytes, fibroblasts and endothelial cells. Upon stimulation, macrophages, T, B, mast, glial cells, eosinophils, keratinocytes and granulocytes also secrete IL-6. This pleiotrophic cytokine influences antigen-specific immune response, inflammatory response, and the development of neurons and is a major mediator of the acute phase reaction.