eBioscience™ Human IFN beta, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 34-8699-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15548826

Quantity Price
1 £ 531.32 / 100µg
Estimated Shipment date
from Supplier 01-06-2017
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Description and Specification

Specification

Biological Activity The ED50 of this protein, as measured by stimulation of human TF-1 cell proliferation, is less than or equal to 0.1ng/mL, which corresponds to a specific activity of at least 1 x 107 units/mg.
Storage Requirements Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier protein (e.g., 0.1% BSA) at less than or equal to -20°C.
Regulatory Status RUO
For Use With (Application) Functional Assays
Molecular Weight 20kDa
Purification Method SDS-PAGE and HPLC
Source CHO Cells
Purity >95%
Structural Form CHO cells (amino acids Met22-Asn187; Accession # AAC41702.1)
Formulation Lyophilized from 10mM sodium citrate, 100mM sodium chloride, and 10mM sucrose
Recombinant Yes
Name IFN beta
Quantity 100μg
Conjugate Unlabeled
Product Type Recombinant Protein, Carrier-Free
Endotoxin Concentration Less than 0.1ng/μg cytokine as determined by the LAL assay
Cross Reactivity Human

Human interferon beta is a glycosylated member of the type I family of interferons, which also includes IFN alpha. Human IFN alpha and beta share 50% amino acid sequence homology and bind the IFN a/b receptor (IFNAR), which consists of two subunits IFNAR1 and IFNAR2, with different affinities. Binding of IFN to its receptor activates signal transduction, including the JAK/STAT and p38 MAPK pathways. Many studies have established IFN beta as a mediator of anti-viral, anti-proliferative, and anti-inflammatory functions, as well as an effective treatment for multiple sclerosis.