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eBioscience™ Human IFN beta, Recombinant Protein, Carrier-Free

Human Recombinant Protein

Brand:  Affymetrix eBioscience 34-8699-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15548826

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Product Support team on 01509 555888 for assistance

Disclaimers:

For Research Use Only.


Description

Description

Human interferon beta is a glycosylated member of the type I family of interferons, which also includes IFN alpha. Human IFN alpha and beta share 50% amino acid sequence homology and bind the IFN a/b receptor (IFNAR), which consists of two subunits IFNAR1 and IFNAR2, with different affinities. Binding of IFN to its receptor activates signal transduction, including the JAK/STAT and p38 MAPK pathways. Many studies have established IFN beta as a mediator of anti-viral, anti-proliferative, and anti-inflammatory functions, as well as an effective treatment for multiple sclerosis.
Specifications

Specifications

Functional Assays
20kDa
SDS-PAGE and HPLC
100μg
Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier protein (e.g., 0.1% BSA) at less than or equal to -20°C.
CHO cells (amino acids Met22-Asn187; Accession # AAC41702.1)
The ED50 of this protein, as measured by stimulation of human TF-1 cell proliferation, is less than or equal to 0.1ng/mL, which corresponds to a specific activity of at least 1 x 107 units/mg.
Unlabeled
Yes
Lyophilized from 10mM sodium citrate, 100mM sodium chloride, and 10mM sucrose
IFN beta
>95%
CHO Cells
RUO
Less than 0.1ng/μg cytokine as determined by the LAL assay
Recombinant Protein, Carrier-Free
Human