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Invitrogen™ eBioscience™ Human IL-21, Recombinant Protein

Human Recombinant Protein

Brand:  Invitrogen™ 14-8219-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15132139

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Disclaimers:

For Research Use Only.


Description

Description

Human Interleukin-21 (IL-21) is a 131-amino acid protein with 57% identity to the mouse gene. It contains a 24-amino acid signal peptide and a 4-helix-bundle cytokine domain homologous to IL-2, IL-4 and IL-15. IL-21 stimulates B cell proliferation in an anti-CD40 dependent manner but inhibits B cell proliferation stimulated by IL-4 plus anti-IgM. IL-21 is induced by IL-6 in activated T cells, a process that is dependent on STAT3 but not on ROR-gamma. IL-21 induces Th17 differentiation and suppresses FOXP3 expression, which requires STAT3 and ROR-gamma.
Specifications

Specifications

NM_021803
Cytokine Bioassays, ELISA Recombinant Standard
The protein has a predicted molecular mass of 17,150. The DTT reduced protein migrates as a 18kDa polypeptide on SDS-PAGE. The non-reduced protein migrates as a 17kDa polypeptide.
SDS-PAGE
25μg
RUO
Less than 0.01ng/ug cytokine as determined by the LAL assay.
ELISA, FA
Unlabeled
Yes
0.1mg/mL
Sterile liquid; 20mM sodium phosphate, pH 7.2, 0.6M NaCl, 1.0% BSA. 0.22μm filtered.
IL-21
>98%
E. coli
A DNA sequence encoding the mature form of human IL-21amino acids Gln25-Ser155 accession # NM_021803 was expressed in E.coli
Interleukin-21, IL21
The ED50 of this protein, as measured by B9 cell proliferation assay, is less than or equal to 25ng/mL. This corresponds to a specific activity of greater than or equal to 4 x 104 Units/mg.
Human
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