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Invitrogen™ eBioscience™ Human IL-21, Recombinant Protein

Human Recombinant Protein

Brand:  Invitrogen™ 14-8219-62

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15517516

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Product Support team on 01509 555888 for assistance



Human Interleukin-21 (IL-21) is a 131-amino acid protein with 57% identity to the mouse gene. It contains a 24-amino acid signal peptide and a 4-helix-bundle cytokine domain homologous to IL-2, IL-4 and IL-15. IL-21 stimulates B cell proliferation in an anti-CD40 dependent manner but inhibits B cell proliferation stimulated by IL-4 plus anti-IgM. IL-21 is induced by IL-6 in activated T cells, a process that is dependent on STAT3 but not on ROR-gamma. IL-21 induces Th17 differentiation and suppresses FOXP3 expression, which requires STAT3 and ROR-gamma.


Cytokine Bioassays , ELISA Recombinant Standard
The protein has a predicted molecular mass of 17,150. The DTT reduced protein migrates as a 18kDa polypeptide on SDS-PAGE. The non-reduced protein migrates as a 17kDa polypeptide.
Store at less than or equal to -70°C.
A DNA sequence encoding the mature form of human IL-21amino acids Gln25-Ser155 accession # NM_021803 was expressed in E.coli
Interleukin-21, IL21
Recombinant Protein
Sterile liquid; 20mM sodium phosphate, pH 7.2, 0.6M NaCl, 1.0% BSA. 0.22μm filtered.
E. coli
Less than 0.01ng/ug cytokine as determined by the LAL assay.
The ED50 of this protein, as measured by B9 cell proliferation assay, is less than or equal to 25ng/mL. This corresponds to a specific activity of greater than or equal to 4 x 104 Units/mg.

For Research Use Only.