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Invitrogen™ IL1RA Human ELISA Kit

For the quantitative detection of human IL-1RA.

Brand:  Invitrogen™ BMS2080

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15561597

  • £377.00 / 96 tests


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal polyclonal antibody to human IL-1RA
Biotin-Conjugate anti-human IL-1RA polyclonal antibody
Streptavidin-HRP
Human IL-1RA Standard lyophilized, 14ng/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

Interleukin 1 receptor antagonist (ILRA) is a protein related to the IL-1 family based on its similarities in amino acid sequence to both IL-1 beta and IL-1 alpha, similarities in gene structure, and collective gene localization. The human gene contains four exons and maps to chromosome 2q13-14. IL-1 RA binds to the IL-1 receptor and blocks IL-1 action through competitive inhibition. In contrast to IL-1, the binding of IL-1RA does not initiate signaling events. The secretion of IL-1 RA is mediated by a classical signal sequence while neither IL-1alpha nor IL-1beta possess such a sequence. The lack of homology between IL-1 RA and IL-1 alpha or IL-1 beta near the N terminus may provide an explanation for the biosynthetic and functional differences between IL-1 RA and the two IL-1 proteins. The production of IL-1RA is stimulated by many substances including adherent IgG, cytokines, and bacterial or viral components. IL-1RA is an important natural anti-inflammatory protein that when missing or just available in inadequate amounts plays a key role in several pathological conditions such as rheumatoid arthritis, colitis, osteomyelitis, periostitis and pustulosis.
Specifications

Specifications

P18510
Biotin
3557
ELISA Kit
30 pg/mL
Plasma, 50 μL|Serum, 50 μL|Supernatant, 50 μL
1 hr. 20 min.
Human
Interleukin-1 receptor antagonist
7.2%
Human
HRP
109-7,000 pg/mL
ELISA
Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
RUO
50 μL
2°C to 8°C
3 hr. 30 min.
DIRA,ICIL-1RA,IL-1RN,IL-1ra,IL-1ra3,IL1F3,IL1RA,IRAP,MVCD4
7.4%
96 Tests
Supernatant
Colorimetric Microplate Reader
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For Research Use Only