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Invitrogen™ eBioscience™ Human CD257 (BAFF, BLyS), Recombinant Protein

Human Recombinant Protein

Brand:  Invitrogen™ 14-8943-62

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15507556

  • POA / 5µg

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Description

Description

Recombinant human BAFF (B-cell activating factor), also referred to as BlyS, is a type II transmembrane protein of the TNF superfamily. BAFF is found on T cells, macrophages and dendritic cells. BAFF contains a cytoplasmic domain, transmembrane domain and extracellular domain which can be cleaved between amino acid 133 and 134 to produce a soluble form detectable in serum. Receptors for BAFF include TACI, BAMBI and BAFFR. BAFF/BLyS is a B lymphocyte stimulatory molecule; it induces B cell proliferation and immunoglobulin secretion. In addition BAFF can provide a co-stimulation signal to T lymphocytes. Elevated levels of BAFF has been implicated in the pathogenesis of some autoimmune diseases (particularly) B cell diseases such as systemic lupus erythaematosus. Human and mouse BAFF share 86% amino acid sequence identity.
Specifications

Specifications

0.1mg/mL
Sterile liquid; 10mM phosphate, 150mM NaCl, 1.0% BSA. 0.22μm filtered.
CD257 (BAFF, BLyS)
>90%
E. coli
RUO
Less than 0.40ng/μg as determined by the LAL assay.
The ED50, as determined by a mouse splenocyte survival assay, is 1.6μg/mL.
Unlabeled
Yes
Cytokine Bioassays
18.5kDa
reducing SDS-PAGE
5μg
Store at less than or equal to -70°C.
E. coli expressed amino acids Ala134 - Leu285 Accession # Q9Y275
B-Cell Activating Factor
Recombinant Protein
Human
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