eBioscience™ Human CD257 (BAFF, BLyS), Recombinant Protein

Human Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8943-62

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15507556

Quantity Price
1 £ 66.65 / 5µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Formulation Sterile liquid; 10mM phosphate, 150mM NaCl, 1.0% BSA. 0.22μm filtered.
Product Type Recombinant Protein
Purity >90%
Gene Symbol B-Cell Activating Factor
Biological Activity The ED50, as determined by a mouse splenocyte survival assay, is 1.6μg/mL.
Purification Method reducing SDS-PAGE
Conjugate Unlabeled
Source E. coli
Structural Form E. coli expressed amino acids Ala134 - Leu285 Accession # Q9Y275
Molecular Weight 18.5kDa
Concentration 0.1mg/mL
For Use With (Application) Cytokine Bioassays
Quantity 5μg
Endotoxin Concentration Less than 0.40ng/μg as determined by the LAL assay.
Storage Requirements Store at less than or equal to -70°C.
Cross Reactivity Human
Recombinant Yes
Name CD257 (BAFF, BLyS)
Regulatory Status RUO

Recombinant human BAFF (B-cell activating factor), also referred to as BlyS, is a type II transmembrane protein of the TNF superfamily. BAFF is found on T cells, macrophages and dendritic cells. BAFF contains a cytoplasmic domain, transmembrane domain and extracellular domain which can be cleaved between amino acid 133 and 134 to produce a soluble form detectable in serum. Receptors for BAFF include TACI, BAMBI and BAFFR. BAFF/BLyS is a B lymphocyte stimulatory molecule; it induces B cell proliferation and immunoglobulin secretion. In addition BAFF can provide a co-stimulation signal to T lymphocytes. Elevated levels of BAFF has been implicated in the pathogenesis of some autoimmune diseases (particularly) B cell diseases such as systemic lupus erythaematosus. Human and mouse BAFF share 86% amino acid sequence identity.