eBioscience™ Mouse CD254 (RANK Ligand), Recombinant Protein

Mouse Recombinant Protein

Brand: eBioscience™

Manufacturer Part Number: 14-8612-62

5UG Mouse RANK Ligand Recombinant Protein

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg

Product Code. 15557546

Quantity Price
1 £129.50 / 5µg
Estimated Shipment date
from Supplier 27-10-2016
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Description and Specification


Concentration 0.1mg/mL
Conjugate Unlabeled
Cross Reactivity Mouse
For Use With (Application) Cytokine Bioassays
Formulation Sterile liquid; phosphate buffered saline, pH 7.2, 1.0% BSA. 0.22μm filtered.
Molecular Weight 20kDa
Name CD254 (RANK Ligand)
Purification Method reducing SDS-PAGE
Purity >90%
Quantity 5μg
Recombinant Yes
Source E. coli
Storage Requirements Store at less than or equal to -70°C.
Regulatory Status RUO
Structural Form E. coli expressed amino acid Lys158 - Asp316 Accession # Q3TWY5
Endotoxin Concentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Gene Symbol RANKL, TRANCE, Receptor Activator for Nuclear Factor kappa B Ligand, Osteoprotegerin ligand, OPGL, ODF, Osteoclast Differentiation Factor
Biological Activity The ED50, as measured by induction of osteoclast formation on mouse RAW264.7 cells, is 4.8ng/mL.
Product Type Recombinant Protein

RANK Ligand (Receptor Activator for Nuclear Factor κB Ligand), also known as TNF-related activation-induced cytokine (TRANCE), along with RANK are members of the TNF superfamily. RANK-L can be found as a soluble protein expressed by activated T lymphocytes, which plays a role in dendritic cell maturation. In addition it has also been shown to be cleaved by TACE (TNF-α convertase) releasing an ectodomain variant of the cell bound form. Lastly RANK-L is expressed as a Type II transmembrane protein expressed by osteoblast lineages. The receptor RANK, located on osteoclastic and dendritic cells can recognize all forms of RANK-L. RANK-L plays a critical role in bone development and mineralization. High levels of RANK-L have been associated with degenerative bone diseases.