eBioscience™ Mouse CD254 (RANK Ligand), Recombinant Protein

Mouse Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8612-62

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15557546

Quantity Price
1 £ 84.99 / 5µg
Estimated Shipment date
from Supplier 01-06-2017
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Description and Specification

Specification

Concentration 0.1mg/mL
Purity >90%
Structural Form E. coli expressed amino acid Lys158 - Asp316 Accession # Q3TWY5
Formulation Sterile liquid; phosphate buffered saline, pH 7.2, 1.0% BSA. 0.22μm filtered.
Endotoxin Concentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Conjugate Unlabeled
Purification Method reducing SDS-PAGE
Name CD254 (RANK Ligand)
Cross Reactivity Mouse
For Use With (Application) Cytokine Bioassays
Molecular Weight 20kDa
Quantity 5μg
Regulatory Status RUO
Recombinant Yes
Product Type Recombinant Protein
Source E. coli
Storage Requirements Store at less than or equal to -70°C.
Gene Symbol RANKL, TRANCE, Receptor Activator for Nuclear Factor kappa B Ligand, Osteoprotegerin ligand, OPGL, ODF, Osteoclast Differentiation Factor
Biological Activity The ED50, as measured by induction of osteoclast formation on mouse RAW264.7 cells, is 4.8ng/mL.

RANK Ligand (Receptor Activator for Nuclear Factor κB Ligand), also known as TNF-related activation-induced cytokine (TRANCE), along with RANK are members of the TNF superfamily. RANK-L can be found as a soluble protein expressed by activated T lymphocytes, which plays a role in dendritic cell maturation. In addition it has also been shown to be cleaved by TACE (TNF-α convertase) releasing an ectodomain variant of the cell bound form. Lastly RANK-L is expressed as a Type II transmembrane protein expressed by osteoblast lineages. The receptor RANK, located on osteoclastic and dendritic cells can recognize all forms of RANK-L. RANK-L plays a critical role in bone development and mineralization. High levels of RANK-L have been associated with degenerative bone diseases.