eBioscience™ Human BMP-2, Recombinant Protein

Human Recombinant Protein

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8507-62

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Product Code. 15507546

Quantity Price
1 £ 78.88 / 5µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Name BMP-2
Source E. coli
Cross Reactivity Human
Recombinant Yes
Structural Form E. coli expressed amino acids Gln283-Arg396 accession number NP_001191
Storage Requirements Store at less than or equal to -70°C.
Accession Number NP_001191
Regulatory Status RUO
Concentration 0.1mg/mL
Purification Method SDS-PAGE
Molecular Weight 13kDa
Purity >97%
Conjugate Unlabeled
Product Type Recombinant Protein
Quantity 5μg
Gene Symbol Bone Morphogenetic Protein 2
For Use With (Application) Cytokine Bioassays
Formulation Sterile liquid; 0.1M glycine, 1% BSA
Endotoxin Concentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Biological Activity The ED50 of this protein, as determined by alkaline phosphatase induction in C3H/10T1/2 cells, is 0.25-1μg/mL. This corresponds to a specific activity of 4x103 - 1x103 Units/mg.

BMP-2 is one of fifteen bone morphogenetic proteins (BMP) belonging to the TGF-β superfamily. The BMPs were first identified as the active factors in demineralized bone matrix, with transcripts later being discovered in many other types of tissue. They are synthesized as large precursor molecules that must be cleaved into their active form and dimerize in order to exhibit functional activity. These dimers may include two identical or distinct BMP chains. BMP responsiveness appears to be limited to multipotent and immature cells. The BMPs are essential for osteogenesis and organogenesis during embryonic development, and also play a role in fracture and wound healing in adults.