eBioscience™ Mouse Flt3 Ligand, Recombinant Protein

Mouse Recombinant Protein

Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-8001-62

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg

Product Code. 15567476

Quantity Price
1 £ 54.42 / 5µg
EU Stock 1
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Description and Specification


Accession Number AL2
Concentration 0.1mg/mL
For Use With (Application) Cytokine Bioassays
Formulation Sterile liquid; 20mM glycine, 150mM NaCl, 1% BSA, pH 3.0
Molecular Weight 20.7kDa
Name Flt3 Ligand
Purification Method SDS-PAGE
Purity >97%
Quantity 5μg
Source E. coli
Storage Requirements Store at less than or equal to -70°C.
Regulatory Status RUO
Structural Form E. coli expressed amino acids Thr28-Gln189 accession number AL2
Endotoxin Concentration Less than 0.05ng/μg cytokine as determined by the LAL assay.
Gene Symbol FL, FLT-3L, FMS-related tyrosine kinase 3 Ligand, Flk-2 Ligand
Biological Activity The ED50 of this protein, as measured by IL-6 induction in M1 cells, is 50-250ng/mL in the presence of 1ng/mL Mouse LIF Recombinant Protein. This corresponds to a specific activity of 2 x 104 - 4 x 103 Units/mg.
Product Type Recombinant Protein
Conjugate Unlabeled
Cross Reactivity Mouse
Recombinant Yes

Flt3 (FMS-related tyrosine kinase 3) Ligand is a growth factor that stimulates the growth and differentiation of early hematopoetic progenitor cells. Flt3 Ligand alone exerts weak biological effects, and instead synergizes with other colony-stimulating factors to induce the proliferation and differentiation of cells of the myeloid and lymphoid lineages. Recent studies have suggested that Flt3 Ligand plays an important role in the development and expansion of dendritic cells in vivo, and that it may influence NK cell survival by this mechanism.

Flt3 Ligand transcripts are detectable in most cell types and tissues, although the protein has only been found in stromal cells and T cells. It is expressed most often as a transmembrane cell surface protein, although processing can yield a soluble, secreted isoform.