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eBioscience™ Human LIF, Recombinant Protein

Human Recombinant Protein

Brand:  Affymetrix eBioscience 14-8460-62

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15537536

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Specifications

Description

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice, and contribute to stem cell self-renewal. LIF can be up-regulated by pro-inflammatory cytokines such as TNF alpha and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
Description & Specifications

Specifications

NM_002309
Cytokine Bioassays , Functional Assays
6.4kDa
SDS-PAGE
5μg
Store at less than or equal to -70°C.
E. coli expressed amino acids Ser23-Phe202, accession number NM_002309
Leukemia Inhibitory Factor, HILDA
Recombinant Protein
Human
0.1mg/mL
Sterile liquid: 0.1M glycine, 1% BSA, pH 3.0
LIF
>97%
E. coli
RUO
Less than 0.01ng/μg cytokine, as determined by the LAL assay.
The ED50 of this protein, as measured by mouse IL-6 induction in M1 cells, is less than or equal to 15ng/mL. This corresponds to a specific activity of greater than or equal to 6.7 x 104 Units/mg.
Unlabeled
Yes