missing translation for 'onlineSavingsMsg'
Learn More

Globo H Monoclonal Antibody (VK9), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£104.00 - £310.00

Specifications

Antigen Globo H
Clone VK9
Concentration 0.5 mg/mL
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15507616
View Documents Promotion Details
Affymetrix eBioscience
14-9700-82
100 μg
£310.00
100µg
View alternative products
Save Up to 
»
In Stock
to see stock.
Please to purchase this item. Need a web account? Register with us today!
15597606
View Documents Promotion Details
Affymetrix eBioscience
14-9700-80
25 μg This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A View alternative products
Save Up to 
»
Description

Description

Description: The VK9 monoclonal antibody recognizes human Globo H, a hexasaccharide formed from the pentasaccharide precursor, SSEA3 (stage-specific embryonic antigen 3). It is a member of a family of antigenic carbohydrates expressed on the surface of cancer cells as glycolipids and possibly glycoproteins. Globo H is overexpressed on many carcinomas, such as breast, colon, ovarian, gastric, pancreatic, lung, and prostate. Expression is observed in more than half of all ductal, lobular, and tubular breast carcinomas, but not in non-epithelial breast tumors. Globo H is also expressed on cancer stem cells and human embryonic stem cells, although expression decreases when cells are differentiated toward both neural progenitor cells and to a lesser extent in endodermal lineage cells. Expression in normal tissues is limited to cells composing secretory borders. Globo H is considered a target for immunotherapy of many epithelial cancers. Applications Reported: This VK9 antibody has been reported for use in flow cytometric analysis, western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and microscopy. Applications Tested: This VK9 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using either high or low pH antigen retrieval at less than or equal to 5 μg/mL.

Globo H is a hexasaccharide formed from the pentasaccharide precursor, SSEA3 (stage-specific embryonic antigen 3). It is a member of a family of antigenic carbohydrates expressed on the surface of cancer cells as glycolipids and possibly glycoproteins. Globo H is overexpressed on many carcinomas, such as breast, colon, ovarian, gastric, pancreatic, lung, and prostate. Expression is observed in more than half of all ductal, lobular, and tubular breast carcinomas, but not in non-epithelial breast tumors. Globo H is also expressed on cancer stem cells and human embryonic stem cells, although expression decreases when cells are differentiated toward both neural progenitor cells and to a lesser extent in endodermal lineage cells. Expression in normal tissues is limited to cells composing secretory borders. Globo H is considered a target for immunotherapy of many epithelial cancers.
Specifications

Specifications

Globo H
0.5 mg/mL
Monoclonal
Liquid
RUO
IgG3 κ
Affinity chromatography
Antibody
VK9
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Mouse
Human
Primary
4° C
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.