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eBioscience™ Human CD154 (CD40 Ligand), sCD154 (sCD40 Ligand), Recombinant Protein, Carrier-Free

Human Recombinant Protein

Brand:  Affymetrix eBioscience 34-8902-85

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15568836

  • £794.22 / 500µg


Estimated Shipment date
from Supplier 25-10-2017
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Description

Description

CD40 ligand, (CD40L, also known as CD154, TRAP or gp39) is a membrane glycoprotein expressed on activated CD4+ T-cells, NK cells, mast cells, basophils and eosinophils. The CD40-CD40L interaction stimulates B cell immune response which includes cell surface antigen expression, cell cycle activation, Ig isotype switching, Ig secretion and memory generation. The CD40-CD40L interaction also plays important roles in monocyte and dendritic cell activation, T-cell co-stimulation and cytokine production. It has been reported that the CD40-CD40L interaction is involved in the pathogenesis of amyloid pathology in Alzheimer disease.
Specifications

Specifications

Functional Assays
CD154 (CD40 Ligand), sCD154 (sCD40 Ligand)
>98%
E. coli
E. coli (amino acids Gln114-Leu261; Accession # NP_000065.1)
CD40L, Tnfsf5, TRAP
The ED50 of this protein, as measured by stimulation of IL-8 production by normal human peripheral blood cells, is less than or equal to 5-10ng/mL.
Human
16.3kDa
SDS-PAGE and HPLC
500μg
RUO
Less than 0.1ng/μg cytokine as determined by the LAL assay
FA
Unlabeled
Yes