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Invitrogen™ BCL-2 Human ELISA Kit

For the quantitative detection of human Bcl-2.

Brand:  Invitrogen™ BMS244-3

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15581817

  • £377.00 / 96 tests


EU Stock 7
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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human Bcl-2
Biotin-Conjugate anti-human Bcl-2 monoclonal antibody
Streptavidin-HRP
Human Bcl-2 Standard lyophilized, 64ng/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Lysis Buffer 10x
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Adhesive Films

Description

Description

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
Specifications

Specifications

P10415
Biotin
596
Pre-coated 96 well plate, Adhesive Plate Covers, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Lysis Buffer, Chromogen, Stop Solution
RUO
20 μL
2°C to 8°C
3 hr. 10 min.
Bcl-2,PPP1R50
12%
HRP
Human
0.50-32.0 ng/mL
ELISA
Colorimetric Microplate Reader
ELISA Kit
<0.5 ng/mL
Cell Lysate,20 μL|Plasma, 20 μL|Serum, 20 μL
1 hr. 20 min.
Human
Apoptosis regulator Bcl-2
8.6%
96 Tests
Serum
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For Research Use Only