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HLA-DR Mouse anti-Canine, Cynomolgus Monkey, Human, Non-human primate, Rhesus Monkey, PE, Clone: L243, eBioscience™

Mouse Monoclonal Antibody

£57.25 - £161.00

Specifications

Antigen HLA-DR
Clone L243
Target Species Canine, Cynomolgus Monkey, Human, Non-human Primate, Rhesus Monkey
Conjugate PE
Isotype IgG2a, kappa
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Product Code Brand Quantity Price Quantity & Availability  
15597276
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Affymetrix eBioscience
12-9952-41
25 Tests £57.25
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15507286
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Affymetrix eBioscience
12-9952-42
100 Tests £161.00
100 tests View alternative products
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In stock, ready to ship: 2 Please to purchase this item. Need a web account? Register with us today!
Description

Description

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
Specifications

Specifications

HLA-DR
Canine, Cynomolgus Monkey, Human, Non-human Primate, Rhesus Monkey
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
L243
PE
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.