HLA-A3 Mouse anti-Human, APC, Clone: GAP.A3, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-5754-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15558126

Quantity Price
1 £ 78.59 / 25 tests
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Conjugate APC
Quantity 25 tests
Regulatory Status RUO
Species Reactivity Human
Applications Flow Cytometry
Isotype IgG2a
Host Species Mouse
Primary or Secondary Primary
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.25μg)/test
Antigen HLA-A3
Monoclonal or Polyclonal Monoclonal
Clone GAP.A3
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The monoclonal antibody GAP.A3 reacts with the human major histocompatibility complex (MHC) class I molecule HLA-A3, which is a member of the HLA-A family. HLA-A3 exists as two subtypes, HLA-A3.1 and HLA-A3.2, which differ at amino acid positions 152 and 156. MHC class I molecules are expressed on all nucleated cells. These molecules are highly polymorphic, cell surface glycoproteins that non-covalently associate with B2 microglobulin. MHC Class I molecules present intracellular peptides on the cell surface and nonnative peptides are recognized by circulating cytotoxic T lymphocytes. HLA-A3 is expressed by 15-25% of cancer patients and has been demonstrated to bind the tumor-associated antigen human telomerase reverse transcriptase (hTERT).