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HIF-1 Mouse, Clone: ESEE122, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9100-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15258147

  • £67.82 / 25µg


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For Research Use Only.


Description

Description

This ESEE122 monoclonal antibody reacts with hypoxia inducible factor-1 alpha. The hypoxia inducible factor (HIF-1) is a transcription factor composed of an inducible alpha form and the constitutively expressed beta form, also called the aryl hydrocarbon receptor nuclear translocator (ARNT). Both alpha and beta subunits of HIF-1 contain basic helix-loop-helix motifs and function to activate transcription of genes in response to reduced oxygen levels. Under normoxic conditions, HIF-1 alpha is rapidly degraded, while HIF-1 alpha expression is induced and degradation inhibited under hypoxic conditions. HIF-1 alpha can be found in the cytoplasm and/or in the nucleus under normoxic conditions, but translocates to the nucleus under hypoxic conditions. HIF-1 is upregulated in several cancer types and functions to control genes involved in angiogenesis, cell survival and T cell development. Recent studies have shown the importance of HIF-1 alpha in balancing Th17 and Treg development.

This ESEE122 antibody has also been reported to cross-react with bovine, rat, and mouse hypoxia inducible factor-1 alpha.
Specifications

Specifications

HIF-1
ESEE122
Unlabeled
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Immunohistochemistry (Formalin/Paraffin)
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
ARNT interacting protein, hypoxia inducible factor-1
IgG1
RUO
Primary
Rat
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