Helios Armenian Hamster, APC, Clone: 22F6, eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-9883-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15518276

Quantity Price
1 £ 223.57999999999998 / 100 tests
EU Stock 6
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Description and Specification

Specification

Gene Alias Ikaros family zinc finger 2
Isotype IgG
Primary or Secondary Primary
Species Reactivity Canine, Human, Mouse
Concentration 5μL (0.0075μg)/test
Conjugate APC
Antigen Helios
Quantity 100 tests
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 22F6
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Format Conjugated
Regulatory Status RUO
Host Species Armenian Hamster
Applications Flow Cytometry (Intracellular Staining)
Monoclonal or Polyclonal Monoclonal

This 22F6 monoclonal antibody reacts with human, mouse and canine Helios. Helios is a zinc-finger transcription factor first identified for its similarity to Ikaros. It is expressed in hematopoietic stem cells in both the embryo and adult mice. While the highest expression is found in regulatory T cells, Helios is not expressed in mature B cells, dendritic cells or myeloid cells. Helios can form a homodimer as well as heterodimerize with other Ikaros family members to regulate transcription. Eight isoforms of Helios exist, some of which possess a dominant-negative function that has also been found to be upregulated in lymphoid malignancies, including T-acute lymphoblastic leukemia.

22F6 has been reported to cross react with rat Helios.