Heat Shock Protein Mouse anti-Human, Clone: STRSN, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9112-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288147

Quantity Price
1 £ 133.91 / 100µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Isotype IgG1
Applications Enzyme Linked Immunosorbent Assay
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Monoclonal or Polyclonal Monoclonal
Clone STRSN
Host Species Mouse
Species Reactivity Human
Primary or Secondary Primary
Conjugate Unlabeled
Gene Alias heat shock protein beta-1, HSPB1, Hsp27
Antigen Heat Shock Protein
Concentration 0.5mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 100μg
Storage Requirements Store at 2-8°C.
Format Purified
Regulatory Status RUO

The monoclonal antibody STRSN recognizes human heat shock protein 27 (HSP27). The heat shock proteins are a large family of proteins that are induced in response to stressors such as changing temperatures, cytokine levels, and presence of various chemicals. Heat shock proteins serve as molecular chaperones, binding to other proteins to maintain proper protein structure or by folding denatured proteins and preventing activation of caspases that could lead to apoptosis. Unlike the larger HSP proteins, HSP27 belongs to a unique subgroup that is involved in apoptosis regulation. Expression of HSP27 is constitutive, but upon stress HSP27 is upregulated and can relocate from the cytoplasm to the nucleus. Increased HSP27 expression with certain carcinomas has been observed. In breast cancer, HSP27 expression has been shown to be responsive to estrogen levels. In both breast cancer and melanoma, high levels of HSP27 correlate with more aggressive tumors and decreased survival. Increased levels of HSP27 in the serum of patients with Chronic Obstructive Pulmonary Disease (COPD), breast cancer and melanoma may serve as a potential diagnostic marker. No crossreactivity is observed with HSP70, 90, 104 or 110.