missing translation for 'onlineSavingsMsg'
Learn More

HDAC8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

£130.00 - £339.00

Specifications

Antigen HDAC8
Concentration 0.14 mg/mL
Applications Immunofluorescence, Immunoprecipitation, Immunocytochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16877454
View Documents Promotion Details
Proteintech
17548-1-AP-20UL
20 μL
£130.00
20µL
View alternative products
Save Up to 
»
Estimated Shipment: 03-05-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
16867454
View Documents Promotion Details
Proteintech
17548-1-AP-150UL
150 μL
£339.00
150µL
View alternative products
Save Up to 
»
Estimated Shipment: 03-05-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
Description

Description

This antibody is a rabbit polyclonal antibody raised against full length HDAC8 of human origin.

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.
Specifications

Specifications

HDAC8
Immunofluorescence, Immunoprecipitation, Immunocytochemistry, Western Blot
Unconjugated
Rabbit
Rat, Mouse, Human
B1WC68, Q8VH37, Q9BY41
363481, 55869, 70315
HDAC8 Fusion Protein Ag11696
Primary
-20°C
HDAC8
0.14 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
HD8, HDAC8, HDACL1, histone deacetylase 8, RPD3
Hdac8
IgG
Antigen Affinity Chromatography
Antibody
Videos
SDS
Documents

Documents

Product Certifications