GW 843682X, Tocris Bioscience™

Selective inhibitor of PLK1 and PLK3

Brand:  RD Systems (Bio-Techne) 29771

Product Code. 13462174

Description

Selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ∽30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.

Chemical Identifiers

• Chemical Name or Material: GW 843682X
• Molecular Formula: C₂₂H₁₈F₃N₃O₄S
• Formula Weight: 477.46
• Synonym: 5-(5, 6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide

Specifications

• Chemical Name or Material: GW 843682X
• Purity Grade: >98%
• Formula Weight: 477.46
• Synonym: 5-(5, 6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide

• CAS: 660868-91-7
• Molecular Formula: C₂₂H₁₈F₃N₃O₄S
• Quantity: 1mg