GW 843682X, Tocris Bioscience™

Selective inhibitor of PLK1 and PLK3

Brand:  RD Systems (Bio-Techne) 29771

Product Code. 13462174

Description

Selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ∽30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.

Chemical Identifiers

• CAS: 660868-91-7
• Molecular Weight (g/mol): 477.458
• Synonym: 5-5,6-dimethoxy-1h-benzimidazol-1-yl-3-2-trifluoromethyl-benzyl oxy thiophene-2-carboxamide, 5-5,6-dimethoxy-1h-benzimidazol-1-yl-3-2-trifluoromethyl benzyl oxy thiophene-2-carboxamide, 5-5,6-dimethoxybenzimidazol-1-yl-3-2-trifluoromethyl phenyl methoxy thiophene-2-carboxamide, kinome_3462, thiophene deriv., 20, bmcl191018 compound 2, gw843682x hplc , solid, 3-2-trifluoromethyl benzyloxy-5-5,6-dimethoxy-1h-benzo d imidazol-1-yl thiophene-2-carboxamide, 5-5,6-dimethoxy-1,3-benzodiazol-1-yl-3-2-trifluoromethyl phenyl methoxy thiophene-2-carboxamide, 5-5,6-dimethoxy-1-benzimidazolyl-3-2-trifluoromethyl phenyl methoxy-2-thiophenecarboxamide
• IUPAC Name: 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide

• Molecular Formula: C22H18F3N3O4S
• InChI Key: JSKUWFIZUALZLX-UHFFFAOYSA-N
• PubChem CID: 9826308
• SMILES: COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC

Specifications

• Chemical Name or Material: GW 843682X
• CAS: 660868-91-7
• Synonym: 5-5,6-dimethoxy-1h-benzimidazol-1-yl-3-2-trifluoromethyl-benzyl oxy thiophene-2-carboxamide, 5-5,6-dimethoxy-1h-benzimidazol-1-yl-3-2-trifluoromethyl benzyl oxy thiophene-2-carboxamide, 5-5,6-dimethoxybenzimidazol-1-yl-3-2-trifluoromethyl phenyl methoxy thiophene-2-carboxamide, kinome_3462, thiophene deriv., 20, bmcl191018 compound 2, gw843682x hplc , solid, 3-2-trifluoromethyl benzyloxy-5-5,6-dimethoxy-1h-benzo d imidazol-1-yl thiophene-2-carboxamide, 5-5,6-dimethoxy-1,3-benzodiazol-1-yl-3-2-trifluoromethyl phenyl methoxy thiophene-2-carboxamide, 5-5,6-dimethoxy-1-benzimidazolyl-3-2-trifluoromethyl phenyl methoxy-2-thiophenecarboxamide
• SMILES: COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC
• Molecular Weight (g/mol): 477.458
• Formula Weight: 477.46

• Quantity: 1mg
• Molecular Formula: C22H18F3N3O4S
• InChI Key: JSKUWFIZUALZLX-UHFFFAOYSA-N
• IUPAC Name: 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide
• PubChem CID: 9826308
• Percent Purity: >98%