GW 843682X, Tocris Bioscience™

Selective inhibitor of PLK1 and PLK3

Brand:  RD Systems (Bio-Techne) 29771

Product Code. 13462174

Description

Selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ∽30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.

Chemical Identifiers

• CAS: 660868-91-7
• Molecular Weight (g/mol): 477.458
• Synonym: 5-(5, 6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide

• Molecular Formula: C22H18F3N3O4S
• InChI Key: JSKUWFIZUALZLX-UHFFFAOYSA-N
• PubChem CID: 9826308

Specifications

• Chemical Name or Material: GW 843682X
• Purity Grade: >98%
• Quantity: 1mg
• InChI Key: JSKUWFIZUALZLX-UHFFFAOYSA-N
• IUPAC Name: 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide
• PubChem CID: 9826308

• CAS: 660868-91-7
• Molecular Formula: C22H18F3N3O4S
• Synonym: 5-(5, 6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide
• SMILES: COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC
• Molecular Weight (g/mol): 477.458
• Formula Weight: 477.46