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GW 583340 dihydrochloride, Tocris Bioscience™

Potent dual EGFR/ErbB2 inhibitor; orally active

Brand:  Tocris (Bio-Techne) 223950

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13460854

  • £674.00 / 50mg


Estimated Shipment
02-07-2018
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Description

Description

Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ∽ 80% in a murine xenograft model following oral administration.
Specifications

Chemical Identifiers

GW 583340 dihydrochloride
C28H25ClFN5O3S2·2HCl
671.03
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride

Specifications

GW 583340 dihydrochloride
1173023-85-2
C28H25ClFN5O3S2·2HCl
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride
50mg
>97%
671.03
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