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GW 583340 dihydrochloride, Tocris Bioscience™

Potent dual EGFR/ErbB2 inhibitor; orally active

Brand:  Tocris (Bio-Techne) 223950

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13460854

  • £674.00 / 50mg


Estimated Shipment
31-08-2018
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Description

Description

Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ∽ 80% in a murine xenograft model following oral administration.
Specifications

Chemical Identifiers

1173023-85-2
671.024
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride
C28H27Cl3FN5O3S2
WIMITXDBYLKRKB-UHFFFAOYSA-N
16219404

Specifications

GW 583340 dihydrochloride
1173023-85-2
C28H27Cl3FN5O3S2
WIMITXDBYLKRKB-UHFFFAOYSA-N
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine;dihydrochloride
16219404
50mg
>97%
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride
CS(=O)(=O)CCNCC1=NC(=CS1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.Cl.Cl
671.024
671.03
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