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GSK J4, Tocris Bioscience™

Histone KDM inhibitor; cell permeable

Brand:  RD Systems (Bio-Techne) 4594/10

Code : Z1

Additional Details : Weight : 0.00010kg

Quantity 10mg

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Product Code. 13464964

  • £178.20 / 10mg


Estimated Shipment
29-10-2018
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Description

Description

Histone lysine demethylase (KDM) inhibitor; blocks demethylation of histone H3K27. Attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9μM for the inhibition of TNFα release). Cell permeable. Ethyl ester derivative of GSK J1 (Cat. No. 4593).
Specifications

Chemical Identifiers

1373423-53-0
417.513
gsk-j4, gsk j4, ethyl 3-6-4,5-dihydro-1h-benzo d azepin-3 2h-yl-2-pyridin-2-yl pyrimidin-4-yl amino propanoate, ethyl 3-2-pyridin-2-yl-6-1,2,4,5-tetrahydro-3-benzazepin-3-yl pyrimidin-4-yl amino propanoate, gskj4, gsk-j hplc, ethyl 3-2-pyridin-2-yl-6-1,2,4,5-tetrahydro-3h-benzo d azepin-3-yl pyrimidin-4-yl amino propanoate, ethyl 3-2-pyridin-2-yl-6-2,3,4,5-tetrahydro-1h-3-benzazepin-3-yl pyrimidin-4-yl amino propanoate, n-2-2-pyridinyl-6-1,2,4,5-tetrahydro-3h-3-benzazepin-3-yl-4-pyrimidinyl-?-alanine ethyl ester, n-2-2-pyridinyl-6-1,2,4,5-tetrahydro-3h-3-benzazepin-3-yl-4-pyrimidinyl-beta-alanine ethyl ester
ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate
C24H27N5O2
WBKCKEHGXNWYMO-UHFFFAOYSA-N
71729975
CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4

Specifications

GSK J4
C24H27N5O2
WBKCKEHGXNWYMO-UHFFFAOYSA-N
ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate
71729975
>99%
1373423-53-0
gsk-j4, gsk j4, ethyl 3-6-4,5-dihydro-1h-benzo d azepin-3 2h-yl-2-pyridin-2-yl pyrimidin-4-yl amino propanoate, ethyl 3-2-pyridin-2-yl-6-1,2,4,5-tetrahydro-3-benzazepin-3-yl pyrimidin-4-yl amino propanoate, gskj4, gsk-j hplc, ethyl 3-2-pyridin-2-yl-6-1,2,4,5-tetrahydro-3h-benzo d azepin-3-yl pyrimidin-4-yl amino propanoate, ethyl 3-2-pyridin-2-yl-6-2,3,4,5-tetrahydro-1h-3-benzazepin-3-yl pyrimidin-4-yl amino propanoate, n-2-2-pyridinyl-6-1,2,4,5-tetrahydro-3h-3-benzazepin-3-yl-4-pyrimidinyl-?-alanine ethyl ester, n-2-2-pyridinyl-6-1,2,4,5-tetrahydro-3h-3-benzazepin-3-yl-4-pyrimidinyl-beta-alanine ethyl ester
CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4
417.513
417.5
10mg
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