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GSK J4, Tocris Bioscience™

Histone KDM inhibitor; cell permeable

Brand:  RD Systems (Bio-Techne) 4594/10

Code : Z1

Additional Details : Weight : 0.00010kg

Quantity 10mg

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Product Code. 13464964

  • £178.20 / 10mg


Estimated Shipment
03-09-2018
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Description

Description

Histone lysine demethylase (KDM) inhibitor; blocks demethylation of histone H3K27. Attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9μM for the inhibition of TNFα release). Cell permeable. Ethyl ester derivative of GSK J1 (Cat. No. 4593).
Specifications

Chemical Identifiers

1373423-53-0
417.513
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
C24H27N5O2
WBKCKEHGXNWYMO-UHFFFAOYSA-N
71729975

Specifications

GSK J4
>99%
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4
417.513
417.5
1373423-53-0
C24H27N5O2
WBKCKEHGXNWYMO-UHFFFAOYSA-N
ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate
71729975
10mg
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