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GSK J1, Tocris Bioscience™

Potent JMJD3/UTX inhibitor

Brand:  RD Systems (Bio-Techne) 4593/10

Code : Z1

Additional Details : Weight : 0.00010kg

Quantity 10mg

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Product Code. 13444964

  • £163.17 / 10mg

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Description

Description

Potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) (IC50 values are 28 and 53 nM respectively). Also inhibits KDM5B, KDM5C and KDM5A (IC50 values are 170, 550 and 6,800 nM respectively). Exhibits no activity against a panel of other histone demethylases (IC50 >20 μM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 μM.

Ethyl ester derivative and Negative Control also available.

Specifications

Chemical Identifiers

1373422-53-7
389.459
gsk-j1, gsk j1, gskj1, 3-2-pyridin-2-yl-6-2,3,4,5-tetrahydro-1h-3-benzazepin-3-yl pyrimidin-4-yl amino propanoic acid, 3-6-4,5-dihydro-1h-benzo d azepin-3 2h-yl-2-pyridin-2-yl pyrimidin-4-yl amino propanoic acid, 3-2-pyridin-2-yl-6-1,2,4,5-tetrahydro-3-benzazepin-3-yl pyrimidin-4-yl amino propanoic acid, k0i, d0s3dd, gskj1; gsk-j1, gsk-j hplc
3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid
C22H23N5O2
AVZCPICCWKMZDT-UHFFFAOYSA-N
56963315
C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CC=CC=N4)NCCC(=O)O

Specifications

GSK J1
C22H23N5O2
AVZCPICCWKMZDT-UHFFFAOYSA-N
3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid
56963315
>99%
1373422-53-7
gsk-j1, gsk j1, gskj1, 3-2-pyridin-2-yl-6-2,3,4,5-tetrahydro-1h-3-benzazepin-3-yl pyrimidin-4-yl amino propanoic acid, 3-6-4,5-dihydro-1h-benzo d azepin-3 2h-yl-2-pyridin-2-yl pyrimidin-4-yl amino propanoic acid, 3-2-pyridin-2-yl-6-1,2,4,5-tetrahydro-3-benzazepin-3-yl pyrimidin-4-yl amino propanoic acid, k0i, d0s3dd, gskj1; gsk-j1, gsk-j hplc
C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CC=CC=N4)NCCC(=O)O
389.459
389.45
10mg
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