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Invitrogen™ GRK1 Recombinant Human Protein

GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases. Full-length recombinant human GRK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

£327.00 - £4915.00

Specifications

Host Species Human
Protein Tag GST Tag
Recombinant Yes
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15488983 View Documents Invitrogen™
PV6352
10μg £327.00
10µg View alternative products
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Estimated Shipment date
from Supplier 22-06-2020
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15498983 View Documents Invitrogen™
PV6353
100μg £1096.00
100µg View alternative products
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»
Estimated Shipment date
from Supplier 22-06-2020
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15418993 View Documents Invitrogen™
PV6354
1mg £4915.00
1mg View alternative products
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»
Estimated Shipment date
from Supplier 22-06-2020
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Description

Description

GRK1 mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin which leads to its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). GRK1 can be phosphorylated by PKA and this reduces the ability of GRK1 to phosphorylate rhodopsin in vitro. It is speculated that phosphorylation of GRK1 by PKA in vivo occurs in the dark when cAMP levels in photoreceptor cells are elevated.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
Specifications

Specifications

Human
GST Tag
Yes