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Granzyme B Rat anti-Mouse, Clone: 16G6, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-8822-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15248097

  • £54.42 / 25µg


Estimated Shipment
02-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

The 16G6 antibody reacts with mouse Granzyme B (GrB) which is a member of the granzyme serine protease family. GrB is found in the granules of cytotoxic T cells and NK cells. Granzyme B has also been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation. GrB has been called CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. GrB is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

For intracellular staining and flow cytometric analysis with direct conjugates of anti-mouse Granzyme B, it is highly recommended to use the Foxp3 Staining Buffer Set (cat. 00-5523). Other buffers may yield varying results. For more information, please contact technical support at tech@ebioscience.com.
Specifications

Specifications

Granzyme B
16G6
Unconjugated
Purified
Rat
25μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, contains carrier protein/stabilizer if necessary
GrzB, GrB
IgG2b
RUO
Primary
Murine