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Granzyme B, clone: 496B, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-8889-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15597546

  • £166.39 / 100Āµg


Estimated Shipment date
from Supplier 03-07-2018
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Description

Description

Description: The 496B antibody reacts with human Granzyme B (GrB). GrB is one of the family of serine proteases, known as granzymes, that is located in the granules of cytotoxic T cells and NK cells. Granzyme B has been described also as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation. GrB has been called CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. GrB is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.Applications Reported: This 496B antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and immunocytochemistry.Applications Tested: This 496B antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded human tissue with low pH antigen retrieval and can be used at less than or equal to 5 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Granzyme B
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P10144
GrB
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ImmunocytochemistryĆ¾Immunohistochemistry
496B
Unconjugated
GZMB
Purified
GZMB
IgG2a, kappa
100μg
Store at 2-8°C.
Primary
3002
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