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Granzyme B Rat anti-Human, Clone: 496B, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-8889-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15587546

  • £55.59 / 25µg


Estimated Shipment date
from Supplier 28-06-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The 496B antibody reacts with human Granzyme B (GrB). GrB is one of the family of serine proteases, known as granzymes, that is located in the granules of cytotoxic T cells and NK cells. Granzyme B has been described also as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation. GrB has been called CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. GrB is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.
Description & Specifications

Specifications

Granzyme B
496B
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IgG2a
RUO
Primary
Human
Immunohistochemistry (Formalin/Paraffin)
0.5mg/mL
Purified
Rat
25μg
Store at 2-8°C.
Monoclonal