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Granzyme B Rat anti-Human, Clone: 496B, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-8889-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15587546

  • £95.00 / 25µg

Estimated Shipment date
from Supplier 24-03-2020

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Description

Description

2 µm post-manufacturing filtered. Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis. Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
Specifications

Specifications

Granzyme B
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P10144
GrB
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
496B
Unconjugated
GZMB
Liquid
GZMB
IgG2a, kappa
25 μg
4° C
Primary
3002
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