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Granzyme A Mouse anti-Mouse, PerCP-eFluor 710, Clone: GzA-3G8.5, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-5831-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15519286

  • £201.85 / 100µg


Estimated Shipment date
from Supplier 04-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This Gza-3G8.5 monoclonal antibody reacts with mouse Granzyme A. Granzyme A is the most abundantly expressed of the ten granzyme serine proteases that have been identified in mice. Granzymes are proteins released from the granules of NK cells and cytotoxic T lymphocytes that induce death in target cells by cleavage of intracellular substrates and play a critical role in immune defense against viruses, tumors, and intracellular bacteria. Granzyme A activates caspase-independent cell death pathways morphologically similar to apoptosis and characterized by mitochondrial and DNA damage. It may also play a role in inflammation, as the precursor form of IL-1 beta (pro-IL-1 beta) is among its target substrates. Granzyme A shares overlapping substrate specificity with the closely-related Granzyme K, which is believed to account for the minimal decrease in cytotoxicity of Granzyme A-deficient CTLs.
Description & Specifications

Specifications

Granzyme A
GzA-3G8.5
PerCP-eFluor 710
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
Conjugated
CTLA-3, Fragmentin-1, TSP-1
IgG2b
RUO
Primary
Murine