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Granzyme A Mouse anti-Mouse, PE-Cy7, Clone: GzA-3G8.5, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 25-5831-82

Code : NEW

Additional Details : Weight : 0.09500kg

 View more versions of this product

Product Code. 15548576

  • £195.05 / 100µg


Estimated Shipment date
from Supplier 30-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

This Gza-3G8.5 monoclonal antibody reacts with mouse Granzyme A. Granzyme A is the most abundantly expressed of the ten granzyme serine proteases that have been identified in mice. Granzymes are proteins released from the granules of NK cells and cytotoxic T lymphocytes that induce death in target cells by cleavage of intracellular substrates and play a critical role in immune defense against viruses, tumors, and intracellular bacteria. Granzyme A activates caspase-independent cell death pathways morphologically similar to apoptosis and characterized by mitochondrial and DNA damage. It may also play a role in inflammation, as the precursor form of IL-1 beta (pro-IL-1 beta) is among its target substrates. Granzyme A shares overlapping substrate specificity with the closely-related Granzyme K, which is believed to account for the minimal decrease in cytotoxicity of Granzyme A-deficient CTLs.
Specifications

Specifications

Granzyme A
GzA-3G8.5
PE-Cy7
Conjugated
Murine
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
CTLA-3, Fragmentin-1, TSP-1
IgG2b
RUO
Primary
Murine