Granzyme A Mouse anti-Mouse, PE-Cy7, Clone: GzA-3G8.5, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 25-5831-80

Product Code. 15538576

Disclaimers:

For Research Use Only.

Description

This Gza-3G8.5 monoclonal antibody reacts with mouse Granzyme A. Granzyme A is the most abundantly expressed of the ten granzyme serine proteases that have been identified in mice. Granzymes are proteins released from the granules of NK cells and cytotoxic T lymphocytes that induce death in target cells by cleavage of intracellular substrates and play a critical role in immune defense against viruses, tumors, and intracellular bacteria. Granzyme A activates caspase-independent cell death pathways morphologically similar to apoptosis and characterized by mitochondrial and DNA damage. It may also play a role in inflammation, as the precursor form of IL-1 beta (pro-IL-1 beta) is among its target substrates. Granzyme A shares overlapping substrate specificity with the closely-related Granzyme K, which is believed to account for the minimal decrease in cytotoxicity of Granzyme A-deficient CTLs.

Specifications

• Antigen: Granzyme A
• Clone: GzA-3G8.5
• Conjugate: PE-Cy7
• Format: Conjugated
• Host Species: Murine
• Quantity: 25μg
• Storage Requirements: Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry (Intracellular Staining)
• Concentration: 0.2mg/mL
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Gene Alias: CTLA-3, Fragmentin-1, TSP-1
• Isotype: IgG2b
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Murine